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Flowchart of the study. CV, cross validation; <t>FFPE,</t> formalin-fixed paraffin-embedded; HES, hematein eosin saffron, HES; ROI, region of interest; slide B <t>RNA+,</t> slide from biopsy sample corresponding to the sample used for the transcriptomic analysis; slide S RNA+, slide from surgical sample corresponding to the sample used for the transcriptomic analysis; slide S RNA-, slide from surgical sample, not corresponding to the sample used for the transcriptomic analysis; SSL, self-supervised learning; TCGA, The Cancer Genome Atlas.
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Flowchart of the study. CV, cross validation; FFPE, formalin-fixed paraffin-embedded; HES, hematein eosin saffron, HES; ROI, region of interest; slide B RNA+, slide from biopsy sample corresponding to the sample used for the transcriptomic analysis; slide S RNA+, slide from surgical sample corresponding to the sample used for the transcriptomic analysis; slide S RNA-, slide from surgical sample, not corresponding to the sample used for the transcriptomic analysis; SSL, self-supervised learning; TCGA, The Cancer Genome Atlas.

Journal: JHEP Reports

Article Title: Self-supervised learning to predict intrahepatic cholangiocarcinoma transcriptomic classes on routine histology

doi: 10.1016/j.jhepr.2025.101675

Figure Lengend Snippet: Flowchart of the study. CV, cross validation; FFPE, formalin-fixed paraffin-embedded; HES, hematein eosin saffron, HES; ROI, region of interest; slide B RNA+, slide from biopsy sample corresponding to the sample used for the transcriptomic analysis; slide S RNA+, slide from surgical sample corresponding to the sample used for the transcriptomic analysis; slide S RNA-, slide from surgical sample, not corresponding to the sample used for the transcriptomic analysis; SSL, self-supervised learning; TCGA, The Cancer Genome Atlas.

Article Snippet: Total RNAs were further isolated by using the Qiagen FFPE RNA extraction kit (RNeasy FFPE kit, Qiagen) for the discovery set and the Recover AllTM Total Nucleic Acid Isolation Kit for the French external validation cohort (Invitrogen, Thermo Fisher Scientific).

Techniques: Biomarker Discovery, Formalin-fixed Paraffin-Embedded